연구원들은 치매 치료를 위해 칸나비스 화합물을 연구합니다 Researchers investigate cannabis compounds to treat Dementia

 
Submitted by Marijuana News on Tue, 11/07/2017 - 08:45
 
하루에 몇 번, 92세의 Lucy Hanson은 작은 캡슐을 복용합니다. 의료용 마리화나입니다.
"사람들은 그것을 행복한 약이라고 부르고 나는 그것을 나의 행복한 약이라고 부릅니다"  Hanson는 웃으면서 말했습니다.
믿기 어렵겠지만 4년 전 Lucy와 이야기할 때, Lucy는 혼란스럽고 쓰러져서 횡설수설했습니다. 그녀는 종종 침대에 누워 가족이나 친구들과 눈을 마주 치지 않습니다.
그녀의 딸은 그녀를 신경클리닉 전문의에게 데려 가서 진단검사를 실시하고 그녀의 모든 약물을 조사했습니다. 전문의는 그녀의 처방약에는 문제가 없다고 말했습니다.
그녀는 막내 딸 Tania Hanson DeYoung이 말했습니다. "Lucy가 치매로 진행되어 앞으로 6개월 정도 밖에 살 수 없을 거라고 전문의는 말했습니다.”
의료 칸나비스 전문 노인 간호사 - Eloise Theisen. Theisen은 Green Health Consultants 팀에 있습니다.
"노인은 가장 빠르게 성장하는 칸나비스 사용자입니다"라고 Theisen은 설명했습니다.
Theisen은 Lucy에게 처방약을 주지 않고 CBD를 주었습니다.
CBD는 칸나비스의 한 타입인 햄프에서 추출한 비 독성입니다.
Lucy의 변화는 놀라웠습니다.
"Lucy는 가장 극적인 반응을 보였습니다"라고 Theisen은 말했습니다.
"나는 어머니를 되찾았습니다" 라고 Lucy의 딸 Tania가 말했습니다.
Lucy는 "미쳤다고 할 줄 알지만 인생을 돌려받은 것 같아요"라고 말했습니다.
KPIX는 비슷한 경험을 말하는 여러 간병인들과 이야기를 나눴습니다.
의료 칸나비스 약국 Harborside 리더 Steve DeAngelo는 "그녀에게 작은 유리 파이프로 칸나비스를 몇 차례 안겨주곤 했었다” 라고 말했습니다.
DeAngelo의 돌아가신 어머니는 진행형 신경퇴행성질환인 알츠하이머병이 있었습니다. 그는 칸나비스가 자기 어머니를 도왔다고 말합니다.
"어머니는 깜짝 놀라지 않았었고 웃었고 육체적으로 덜 동요했습니다"라고 DeAngelo는 말했습니다.
Basil Shaaban은 "정말 기적이었습니다” 라고 말했습니다.
Basil과 형 Farah는 직접 목격했습니다. 그들의 어머니 Tagrid는 약 8년 전에 일찍 발병한 알츠하이머병으로 진단 받았습니다.
그녀의 증상이 악화됨에 따라 의사는 정신병 치료제를 처방했습니다.
"그녀는 이미 꽤 연약한 상태에 있었고, 약이 그녀를 문자 그대로 파괴했습니다”라고 Farah Shaaban이 말했습니다.
형제들은 가족들에게 CBD를 시도하도록 설득했습니다. 어머니의 인격이 돌아왔고 그녀의 동요와 불면증은 사라졌습니다.
"우리는 마침내 어머니가 주무시는 것을 보고 안심했습니다,"Farah Shaaban은 기억했습니다.
Tagrid는 항정신병약을 끊고 그녀의 의사는 호기심이 많았습니다.
Basil Shaaban은 "1년 후 의사들은 우리가 한 일과 방법을 이해하려고 상담하고 있습니다” 라고 말했습니다.
Shaaban 형제들은 CBD의 여러 품종을 시도하고 결국 가장 잘 작동하는 타입을 정했습니다. 그 품종을 "Tagrid 's Strain"이라고 합니다.
이제 권위있는 연구소의 흥미로운 예비 보고서는 칸나비스가 실제로 두뇌를 보호할 수 있음을 시사합니다.
"우리는 식물을 연구하고 있습니다"라고 La Jolla의 Salk Institute for Biological Studies에서 David Schubert 박사는 말했습니다.
Schubert는 알츠하이머병과 같은 신경퇴행성 장애를 연구합니다.
"정말 끔찍한 질병입니다. 합리적 치료법이 없습니다. 속도를 늦출 수 있는 방법은 없습니다. "라고 Schubert는 말했습니다.
Schubert와 그의 팀은 실험실에서 인간의 뇌에서 추출한 신경세포를 성장 시켰습니다.
그들은 알츠하이머병과 관련있는 높은 수준의 독성 단백질을 생산하도록 변형되었습니다.
아밀로이드 베타로 알려진 단백질은 신경세포 내에 축적되어 염증을 일으키고 신경세포를 죽입니다.
"그래서 염증이 주요 원인입니다" 라고 Schubert가 말했습니다.
그 후 과학자들은 뉴런을 칸나비스에 노출시켰습니다. Schubert는 칸나비스가 독성 단백질을 제거한 것을발견했습니다.
칸나비스는 신경세포 내부에서 염증을 막아 뇌 세포가 살아남도록 했습니다.

 

칸나비노이드오일 전문
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"이것은 매우 중요한 발견입니다"라고 샌프란시스코 VA 메디컬 센터에서 알츠하이머병을 연구하는 Michael Weiner 박사는 말합니다.
"이것은 매우 유망한 연구 분야이며 탐구 되어야 합니다"라고 Weiner는 말했습니다.
Weiner는 좋은 임상 연구가 인간에서 이루어질 때까지 사람들은 의학적 효용 목적상 마리화나를 복용하지 말아야한다고 말했습니다.
한 가지 주요한 문제: 칸나비스는 연방법에 따라 불법으로 남아 있기 때문에 연구가 어렵습니다.
Schubert는 이것이 발전을 막고 있다고 생각합니다.
"엄청난 속도로 방해하고 있습니다" 라고 Schubert가 말했습니다.
Lucy의 딸은 확신합니다.
"칸나비스가 신중히 연구되기를 기다렸더라면 우리 엄마는 죽었을 것입니다" 라고 Tania는 말했습니다.
"감히 엄마를 가져가려고!" 그녀는 웃었습니다.

A few times a day, 92-year-old Lucy Hanson takes a little capsule; in it is medical marijuana.
“They call it my happy pill and I call it my happy pill,” Hanson laughs.
It’s hard to believe when you talk to her now but, four years ago, Lucy was confused, falling down and speaking gibberish. She often lay in bed and would make no eye contact with her family or friends.
Her daughter brought her to a neurology clinic where specialists ran diagnostic tests and looked over all of her medications. They said the problems were not with her prescription drugs.
“They came back with a diagnosis of advanced dementia,” said her youngest daughter Tania Hanson DeYoung, adding “We thought we’d only have her for another six months.”
Enter Eloise Theisen, a geriatric nurse-practitioner who specializes in medical cannabis. Theisen is on the team at Green Health Consultants.
“Seniors are the fastest-growing demographic of cannabis users,” explained Theisen.
Theisen weaned Lucy off some medications and then put her on cannabidiol or CBD, for short.
CBD is a non-intoxicating form of cannabis that’s derived from hemp.
The change in Lucy was remarkable.
“Lucy’s had one of the most dramatic responses,” remarked Theisen.
“I got my mother back,” said Hanson’s daughter Tania.
“I know it sounds crazy but it seems like I was given back a life,” exclaimed Hanson.
KPIX has spoken to several different caregivers who recount similar experiences.
“I would give her a couple of hits of cannabis off a little glass pipe,” said Steve DeAngelo, who heads up Harborside, a medical cannabis dispensary.
DeAngelo’s late mother had Alzheimer’s, a progressive neuro-degenerative disease. He says cannabis helped her.
“She would stop frowning, she would start smiling and she would be less physically agitated,” said DeAngelo.
“It was really an overnight miracle,” exclaimed Basil Shaaban.
Basil and his brother Farah saw it with their own eyes. Their mother Tagrid was diagnosed with early-onset Alzheimer’s Disease about eight years ago.
As her symptoms worsened, doctors put her on anti-psychotic drugs.
“She was already in a pretty fragile state and these drugs came in and they literally destroyed her … whatever she had left of her,” said Farah Shaaban.
The brothers convinced family members to let them try CBD. Their mother’s personality returned and her agitation and insomnia disappeared.
“We were so relieved that she would finally be able to sleep,” Farah Shaaban remembers.
Tagrid is off anti-psychotics and her doctors were curious.
“Now a year later they’re consulting with us to try to understand what it is that we did and how they can learn from it and apply it in their own practice,” Basil Shaaban said.
The Shaaban brothers tried different strains of CBD and finally settled on one that worked the best: they call it “Tagrid’s Strain.”
Now, an intriguing preliminary report out of a prestigious research institute suggests cannabis may actually protect the brain.
“We were looking at botanicals,” said Dr. David Schubert, with the Salk Institute for Biological Studies in La Jolla.
Schubert studies neuro-degenerative disorders like Alzheimer’s.
“It’s just a really horrible disease. There is no reasonable therapy. There is nothing that can slow it down,” said Schubert.
In a dish in his lab, Schubert and his team grew nerve cells taken from a human brain.
They were altered to produce high levels of a toxic protein linked to Alzheimer’s disease.
The protein known as amyloid beta builds up within the neuron, causing inflammation, and killing it.
“So inflammation is a major driving force,” said Schubert.
The scientist then exposed the neurons to cannabis. He found cannabis cleared away the toxic protein.
It stopped the inflammation from inside the neuron and that allowed the brain cells to survive.
“It’s a very important discovery,” says Dr. Michael Weiner, who conducts Alzheimer’s research at the San Francisco VA Medical Center.
“This is a very promising area of research and should be explored,” said Weiner.
Weiner said until good clinical studies are done in humans, people should not try to take marijuana for a medical benefit.
One major problem: cannabis remains illegal under federal law, making it tough to study.
Schubert believes that has slowed progress.
“It’s slowed it down a tremendous amount,” Schubert said.
Lucy Hanson’s daughter is convinced.
“She’d be dead if we had waited for it to be carefully studied, my mom would be dead,” said Tania.
As for Lucy? “Don’t you dare take it away from me,” she laughed.