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체내칸나비노이드체계(ECS) - 치료 타겟 The Endocannabinoid System – As a therapeutic target

by 신의 선물 CBD 2017. 11. 20.
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많은 질병 증상을 치료하는데 있어 CBD 같은 칸나비노이드의 효율성은 몸의 체내칸나비노이드체계 (endocannabinoid system, ECS) 달려 있습니다.다시 말해 몸은 식물에서 추출한 이들 화합물과 결합하는 특별한 수용체를 갖게 고안되었습니다.

ECS 작동할 믿을  없는 일들이 몸에서 일어납니다아직 완전히 이해되지 않았지만 원치 않는 부작용의 위험 없이 많은 사람들을 치료합니다그런데 ECS 무엇이며 CBD 치료를 최대한 활용하는  어떻게 도움이 됩니까아래 라인을 살펴보고 그것에 대해  자세히 알아 보겠습니다.
The efficiency of cannabinoids, such as CBD, to treat the symptoms caused by so many illnesses lies in the endocannabinoid system of our own body. In other words, we were designed to have special receptors that bind with these compounds extracted from plants.
And when they do, incredible things happen in our body, things that are not yet fully understood but manage to provide relief to so many people out there without the risk of suffering unwanted side-effects. But, what is the endocannabinoid system and how does it help us get the most out of CBD treatments? Let us look at the lines below and find out more about it.


 

칸나비노이드오일 전문
www.dopzamall.com/cannabinoid

 


ECS 무엇인가? What is the Endocannabinoid System?

 

ECS 세포 수용체와  인접 분자로 구성됩니다이들 수용체는 자물쇠와 같아서 특정 열쇠로만   있거나  경우 특정 열쇠에만 반응을 일으킵니다해부학적으로 열쇠를 작용제 (agonist) 라고 하는데 열쇠는 몸에서 광범위한 반응을 일으킬  있는 작은 화학 분자입니다.
그래서 작용제가 수용체 세포를 만날 때마다 수용체를 활성화 시키거나 수용체가 해야  일을 알려주는 메시지를 전송하기도 합니다.
이와 같이 ECS에는 몸에 작용하는 수용체의 2가지 주요 유형이 있으며, Cannabinoid Receptor 1 또는 CB1 Cannabinoid Receptor 2 또는 CB2 대해 이야기하고 있습니다.
 수용체의 열쇠나 작용제가 체내칸나비노이드입니다. "Endo" "내부" 번역될  있으며, "칸나비노이드" 칸나비노이드 수용체 내에서 적합 이상으로 화합물에 대한 참조를 합니다.
몸에는 2가지 종류의 체내칸나비노이드가 있는데가장 흥미로운 것은 아난다마이드 (anandamide)  2-Ag입니다아난다마이드는 THC 도움을 받아 발견되었으며,일단 칸나비스의 정신반응 성분이 이스라엘 과학자 Raphael Mechoulam 의해 1960년대에 발견되었습니다.
THC
 발견되자 사람들은 THC 실제로 무엇을 작동시키는 지와 몸이 THC 같은 종류의 분자를 생산할 기회가 있는지 알고 싶어했습니다아난다마이드를 찾아 분리하는  20 이상 걸렸습니다.
 체내칸나비노이드의 이름은 그것이 분리되었을  어떻게 이름을 지을지 모르기 때문에 흥미로웠습니다

과학자들은 Sanskrit에서 "행복" 의미하는 "Ananda"라는 단어를 발견했습니다그래서아난드는 소위 "행복 분자"입니다.
The ECS or Endocannabinoid System is composed out of cell receptors and their adjacent molecules. These receptors act pretty much like locks, as only specific keys can open them up or, in this case, make them react. In anatomy, the keys to these locks are called agonists, which are small chemical molecules capable of triggering a wide range of reactions in the body.
So, each time an agonist meets a receptor cell, it will activate it, but it will also transmit a message as well, letting the receptor know what it has to do.
Thus, when it comes to the ECS, there are two main types of receptors that make its body, and we are talking about Cannabinoid Receptor 1 or CB1 and Cannabinoid Receptor 2 or CB2.
The keys or agonists of these receptors are the endocannabinoids. “Endo” can be translated as “within” and “cannabinoid” makes reference to a compound that is more than suitable for fit within the cannabinoid receptors.
In our body, there are two kinds of endocannabinoids that interest us the most, which are anandamide and 2-Ag. Anandamide was discovered with the help of THC, once this psychoactive component of cannabis was discovered back in the 1960s, by Raphael Mechoulam, an Israeli scientist.
Once THC was discovered, everybody wanted to know what it actually works and if there is a chance for our body to produce the same kind of molecules. It took more than 20 years to find and isolate anandamide.
The name of this endocannabinoid is also interesting as, because they didn’t know how to name it once it was isolated, scientists found the word “Ananda”, in Sanskrit, which means “bliss”. So, yes, anandamides are the so-called “bliss molecules”.



 

치료 타겟으로서의 ECS    The Endocannabinoid System as a therapeutic target

 

ECS 돌아가서몸은 창조된 대로  사람이 자기 몸에서  ECS 활성화 시킨다는 것이 의미가 있습니다.
ECS
 주요 역할은  전체에 퍼져 나가는 것처럼 생리수준에서 웰빙 상태를 유지하는 것입니다.
따라서  질환각종 장기 질환근골격계 문제염증  면역계 문제를 관리하는  도움이   있습니다.
이러한 문제의 원하지 않는 증상을 줄이기 위해 몸은 항상 칸나비노이드를 생산하는데이는 칸나비스에서 추출된 THC 또는 CBD 거의 유사합니다.
몸은 놀랍기 때문에 건강상태를 유지하는  도움이 되도록  칸나비노이드를 만드는 시기와 사용법을 알고 있습니다.
물론 ECS 제대로 작동하지 않는 경우앓고있는 건강 문제를 관리하는  어려움을 겪게 됩니다 경우 몸이 만드는 것과 동일한 구조와 목적을 가진칸나비스 식물에서 추출한 칸나비노이드를 적정량 첨가하여 ECS 도와줄  있습니다.
가장 좋은 점은 아주 적은 양의 칸나비스로기분이 좋고질병으로 인한 증상을 완화하고, ECS 스스로를 상향 조절할  있게 한다는 점입니다
ECS
 규제하는 기능은 무엇입니까?
식욕수면기분소화굶주림면역기능운동조절쾌락  보상다산  생식기억력통증  체온조절능력
이와 같이 ECS 많은 과정을 담당하고 있기 때문에 ECS 치료에 매우 중요하다는 것을 쉽게 이해할  있습니다.
Getting back to the endocannabinoid system, it is worth mentioning that each person has this system active in his or her body, as it is part of the way we are created.
Its main role is to maintain a state of well-being at a physiological level, as it is spread throughout our entire body.
Thus, it can help with the management of brain disorders, various organs illnesses, musculoskeletal problems, inflammatory and immune system problems.
To reduce the unwanted symptoms of these problems, our body produces cannabinoids all the time, which work pretty much like THC or CBD, which is extracted from cannabis.
Because our body is amazing, it knows when to make these cannabinoids and how to use them, in order to help us preserve a great state of health.
Of course, there are cases in which the ECS is not working as it should and we end up having difficulties managing the health problems we may be suffering from. Thus, we can all aid our ECSby adding the right dose of cannabinoids extracted from the cannabis plant, which has the same structure and purpose as those created by our own body.
The best part is that we need very low doses of cannabis in order to feel better, enjoy relief from the symptoms created by your illness, and help your system to up-regulate itself. What are, more precisely, the functions regulated by ECS?
Our appetite, sleep, mood, digestion, hunger, immune function, motor control, pleasure and reward, fertility and reproduction, memory, pain, and the ability to regulate body temperature. So, since the ECS is in charge of so many processes, it is easy to understand that it has a great therapeutic importance.


 
다양한 질병을 치료할  있는 가능성
Great potential to treating various conditions

 

ECS 다양한 질병을 보다 효율적으로 치료할   잠재력을 발휘하기 때문에 여러 제약 전략에서 고려되기 시작했습니다.
연구에 따르면 ECS 활동조절은 불안장애기분장애파킨슨병헌팅턴병다발성경화증신경병증성 통증척수손상죽상동맥경화증심근경색고혈압뇌졸중녹내장골다공증  많은 질병을 치료합니다.
많은 사람들은 칸나비노이드 복용으로 인해 정신자극적 경험을 경험하게 될지 모른다고 우려하고 있지만 과학자는 구성  사용된 복용량을 면밀히 관찰하면 이러한 정신자극 효과가 발생할 위험이 없다고 주장합니다.
칸나비스 식물에 함유된 모든 칸나비노이드가 정신자극 효과를 제공하는 것은 아니라는 것을 고려하면그러한 진술은 유효하며 가까운 장래에 칸나비노이드가 실제 처치로 전환할 기회를 나타냅니다.
In fact, ECS is starting to be considered in the various pharmaceutical strategies as it presents a great potential when it comes to treating various conditions more efficiently.
According to studies, modulating the activity of the ECS can help in a wide range of conditions, such as anxiety disorders, mood disorders, Parkinson’s, Huntington’s, multiple sclerosisneuropathic pain, spinal cord injury, cancer, atherosclerosis, myocardial infarction, hypertension, stroke, glaucoma, osteoporosis, and the list may continue.
While many people fear that taking cannabinoids will make them experience psychoactive experiences, scientist state that there is no risk for these psychoactive effects to occur if the composition and used dose are carefully monitored.
Considering that not all cannabinoids contained in the cannabis plant provide psychoactive effects, such a statement is valid and does represent the chance for cannabinoids to turn into real treatments in the near future.


 

ECS 타겟으로 하는 약품들 Pharmaceutical drugs that target the ECS

 

현재 다양한 장애로 고통받는 환자에게 보다 효과적 치료법을 제공할 목적으로 ECS 타깃으로 하기 위해만들어진 클리닉에는  가지 제약품이 있습니다. Sativex, Dronabinol, Cesamet  Marinol은 모두 CB1  CB2 수용체를 활성화시키는 약물 입니다.
Cesamet
 Marinol 메스꺼움과 구토를 위해 처방되고, Marinol은 또한 식욕자극에 사용되며, Sativex 암과 다발성경화증과 같은 다양한 조건에 의해 유발되는 통증관리에 사용됩니다.
칸나비디올은 또한 류마티스 관절염죽상경화증당뇨병알츠하이머병우울증고혈압 등의 유망한 치료법으로 염증과 산화 스트레스를 줄이는  매우 효과적이라는 것이 발견되었습니다.
그러나 식물에서 추출한 칸나비노이드를 이용한 ECS 활성화는 지금까지 풀린 과학 연구에서 제공한 수많은 긍정적 결과로 인해 착취의 가치가 있는 전략입니다.
우리는 아직도 이것에 대해 배울 많은 것들을 가지고 있지만 적어도  세계적으로 매우 많은 사람들에게  안전하고 효과적 치료를 가져올  있는 문을 열었습니다.
At the moment, there are a few pharmaceutical products in clinics that were created to target ECS, with the purpose of providing a more effective treatment for patients suffering from various disorders. Sativex, Dronabinol, Cesamet, and Marinol are all drugs that will activate the CB1 and CB2 receptors.
Cesamet and Marinol are prescribed for nausea and vomiting, Marinol is also used to appetite stimulation, and Sativex is used for the management of pain caused by a wide range of conditions, including cancer and multiple sclerosis.
Cannabidiol was also discovered to be highly effective in reducing inflammation and oxidative stress, which makes it a promising treatment for rheumatoid arthritis, atherosclerosis, diabetes, Alzheimer’s, depression, hypertension, and so on.
However we put it, the activation of the ECS with cannabinoids extracted from plants is a strategy that is definitely worthy of exploiting due to the numerous positive results it provided in the scientific studies that were unrolled so far.
We may have many things to learn about this still, but at least we made a step forward, opening a door that can bring safer and more effective treatments to a very large number of people worldwide.

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