#Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death.
NCBI
PubMed
US National Library of Medicine
National Institutes of Health
J Pharmacol Exp Ther. 2009 Mar;328(3):708-14. doi: 10.1124/jpet.108.147181. Epub 2008 Dec 12.
Pan H1, Mukhopadhyay P, Rajesh M, Patel V, Mukhopadhyay B, Gao B, Haskó G, Pacher P.
Author information
Abstract
#백금화합물 #cisplatin 은 다양한 #악성종양 을 치료할 수 있는 가장 강력한 화학요법 중 하나입니다.
#신장독성 은 #시스플라틴 화학요법의 일반적 합병증으로, 산화 및 #니트로사티브 스트레스가 증가하여 임상사용이 제한됩니다.
이 연구에서는 #항산화 효과를 나타내는 비-정신자극 칸나비노이드 #CBD 효과를 조사하였으며, 최근 시스플라틴-쥐 모델에서 환자의 #다발성경화증 관련 #염증 #통증 #경련 치료에 대한 승인을 받았습니다.
유도된 nephropathy.
Cisplatin은 superoxide 생성효소 RENOX (NOX4)와 NOX1의 발현을 증가시켰고, 반응성 산소 종 생성, 유도성 nitric oxide synthase 발현, nitrotyrosine 형성, apoptosis (caspase-3/7 활성, DNA fragmentation 및 terminal deoxynucleotidyl transferase dUp nick #종양괴사인자 - 알파 및 인터루킨 -1 베타)의 병리적 연구를 통해 쥐의 신장에서 현저한 조직병리적 손상 및 신장기능 장애 (혈청요소 질소 증가 및 크레아티닌 수치)를 측정 하였습니다.
#CBD 로 쥐를 치료하면 신장의 시스플라틴 유도 산화/니트로사티브 스트레스, 염증 및 #세포사멸 이 현저히 감소되어 신장기능이 개선되었습니다.
따라서, 결과는 CBD가 cisplatin에 의한 #신장독성 에 대한 유망한 새로운 방호전략이 될 수 있음을 시사합니다
칸나비노이드 전문
The platinum compound cisplatin is one of the most potent chemotherapy agents available to treat various malignancies. Nephrotoxicity is a common complication of cisplatin chemotherapy, which involves increased oxidative and nitrosative stress, limiting its clinical use. In this study, we have investigated the effects of a nonpsychoactive cannabinoid cannabidiol, which was reported to exert antioxidant effects and has recently been approved for the treatment of inflammation, pain, and spasticity associated with multiple sclerosis in patients in a mouse model of cisplatin-induced nephropathy. Cisplatin induced increased expression of superoxide-generating enzymes RENOX (NOX4) and NOX1, enhanced reactive oxygen species generation, inducible nitric-oxide synthase expression, nitrotyrosine formation, apoptosis (caspase-3/7 activity, DNA fragmentation, and terminal deoxynucleotidyl transferase dUTP nick-end labeling staining), poly(ADP-ribose) polymerase activity, and inflammation (tumor necrosis factor-alpha and interleukin-1beta) in the kidneys of mice, associated with marked histopathological damage and impaired renal function (elevated serum blood urea nitrogen and creatinine levels) 72 h after the administration of the drug. Treatment of mice with cannabidiol markedly attenuated the cisplatin-induced oxidative/nitrosative stress, inflammation, and cell death in the kidney, and it improved renal function. Thus, our results suggest that cannabidiol may represent a promising new protective strategy against cisplatin-induced nephrotoxicity.
PMID: 19074681 PMCID: PMC2682269 DOI:10.1124/jpet.108.147181
[Indexed for MEDLINE] Free PMC Article
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