October 26, 2015
Cannabidiol 또는 CBD는 칸나비스에 있는 주요 칸나비노이드 중 하나입니다.
연구 결과에 따르면 안전하고 효과적으로 다양한 치료 효능을 제공합니다.
Cannabidiol, or CBD, is one of the
major cannabinoids found in cannabis. Studies have shown it safely and
effectively provides a plethora of therapeutic benefits.
CBD 개요 OVERVIEW OF CBD
칸나비스의 테트라하이드로칸나비놀(tetrahydrocannabinol,
THC)이 관심을 끌 수 있는 칸나비노이드이지만, CBD의 치료 효능에 대한 최근의 놀라운 연구 결과는 마침내 비-향정신성 (non-psychoactive)
화합물을 주목하게 만들고 있습니다.
CBD 수준은 마리화나 식물의 종류에 따라 다르지만, 육종가들은 CBD가 많은 품종을 만들 수 있습니다.
While cannabis’ tetrahydrocannabinol (THC) is the cannabinoid that gets most of
the attention, the relatively recent monumental findings on the therapeutic
benefits of cannabidiol (CBD) are
finally giving the non-psychoactive compound its due shine. CBD levels vary among different strains
of marijuana plants, but breeders are able to create varieties with high levels
of CBD.
햄프오일 전문
CBD의 효능에 대한 칸나비스의 효능
FINDINGS: EFFECTS OF CANNABIS ON EFFECTS OF CBD
연구결과에 따르면 CBD는 구역 및 구토를 안전하고 효과적으로 감소시키고 발작활동을 억제하며 정신병을 퇴치하고 염증질환을 경쟁하고 신경퇴행성 장애를 해결하며 종양과 암세포와 싸우며 불안과 우울 장애를 치료합니다(Fernandez-Ruiz, 2013).
이러한 주목할 만한 효과로 인해 CBD는 신경염증질환, 간질, 산화손상, 구토 및 메스꺼움, 불안 및 정신분열증에 대한 치료 방법으로서 흥미진진한 잠재력을 보여줍니다(Fernandez-Ruiz, et al., 2013).
Studies have shown that CBD safely
and effectively reduces nausea and vomiting, suppresses seizure activity,
combats psychosis disorders, contests inflammatory disorders, counters
neurodegenerative disorders, fights tumor and cancer cells, and battles anxiety
and depression disorders (Fernandez-Ruiz, et al., 2013). Because of these
notable effects, CBD shows exciting
potential as a treatment option for neuroinflammation disorders, epilepsy,
oxidative injury, vomiting and nausea, and anxiety and schizophrenia
(Fernandez-Ruiz, et al., 2013).
알츠하이머 병 Alzheimer’s Disease
CBD는 소교신경(microglial) 활성화를 차단하여 신경을 보호함으로써 알츠하이머병의 진행을 제한 합니다(Martin-Moreno, 등, 2011) (Ramirez, et al., 2005) (Campbell &
Gowran, 2007).
CBD의 신경보호, 항산화 및 항암 효능은 알츠하이머병과 관련된 산화 스트레스를 감소시킵니다 (Iuvone,
et al., 2004).
CBD limits the progression of
Alzheimer’s disease by blocking microglial activation and thus providing
neuroprotection (Martin-Moreno, et al., 2011) (Ramirez, et al., 2005) (Campbell
& Gowran, 2007). The combination of neuroprotective, anti-oxidative and
anti-apoptotic effects provided by CBD
decreases the oxidative stress associated with Alzheimer’s disease. (Iuvone, et
al., 2004).
Amytotraphic 측면 경화증 (ALS) Amytotraphic Lateral Sclerosis (ALS)
CBD는 ALS의 발병을 유의하게 늦출 수 있습니다(Weydt, et al., 2005).
또한 ALS와 일반적으로 관련된 통증, 식욕상실, 우울증, 수면장애, 경련 및 침을 줄일 수 있습니다(Amtmann, et al.,
2004) (Carter, Abood, Aggarwal & Weiss, 2010).
CBD can significantly slow the onset
of ALS (Weydt, et al., 2005). In addition, it can help reduce the pain,
appetite loss, depression, sleeping problems, spasticity and drooling that can
are commonly associated with ALS (Amtmann, et al., 2004) (Carter, Abood,
Aggarwal & Weiss, 2010).
불안 장애 Anxiety Disorder
CBD는 불안장애를 줄이기 위해 뇌의 변연계와 paralimbic 부위에 영향을 미치고 주관적 불안을 현저히 감소시키는 능력을 보여주었습니다(Crippa, et al., 2011).
또한 사회불안장애(SAD)를 가진 사람들의 대중 연설과 관련된 불안, 인지장애 및 불편 함을 현저하게 감소시키는 것으로 나타났습니다(Bergamaschi, et al., 2011).
CBD has effects on the limbic and
paralimbic areas of the brain to reduce anxiety and has demonstrated the
ability to significantly decrease subjective anxiety (Crippa, et al., 2011).
It’s also been shown to significantly reduce the anxiety, cognitive impairment
and discomfort associated with public speaking in individuals with Generalized
Social Anxiety Disorder (SAD) (Bergamaschi, et al., 2011).
관절염 Arthritis
CBD는 관절염을 예방하는 항-염증 효과와 강력한 항-관절염 효과로 관절염 진행을 제한합니다 (Malfait, et al., 2000).
With its anti-inflammatory benefits and potent anti-arthritic effects that
protect joints, CBD limits the
progression of arthritis (Malfait, et al., 2000).
뼈 건강 Bone Health
CBD는 뼈를 함께 붙잡고 있는 뼈의 결합 조직에 있는 단백질인 콜라겐의 성숙을 향상시켜 뼈의 강도와 치유 과정을 크게 향상시킵니다(Kogan, et al., 2015).
CBD enhances the maturation of
collagen, the protein in the bone’s connective tissue that holds the bone
together, which in turn significantly improves the strength and the healing
process of bones (Kogan, et al., 2015).
암 Cancer
CBD는 동물모델에서 유방, 폐, 전립선 및 결장에 있는 암 진행을 억제하여 사람 피험자의 암세포 사멸을 매개하는 데에도 효과적일 수 있다고 제시했습니다(McAllister, Soroceanu &
Desprez, 2015) (Orellana-Serradell, et al., 2015) (Ligresti, et al., 2006).
유방암 세포의 증식과 침입을 억제하고 유방암 세포의 유전자 발현을 감소시켜 종양의 공격성을 낮추고 크기를 현저하게 줄이는 것으로 나타났습니다(McAllister, et
al., 2007). CBD산(CBDA)은 침윤성 뇌암세포를 하향 조절하여 이들의 성장을 억제하는 능력을 보였습니다 (Takeda,
et al., 2014) (McAllister, et al., 2011).
CBD inhibits the progression of
cancers located in the breast, lung, prostate and colon in animal models, which
suggests that it could also be effective at mediating cancer cell death in
human subjects (McAllister, Soroceanu & Desprez, 2015) (Orellana-Serradell,
et al., 2015) (Ligresti, et al., 2006). It’s been shown to inhibit human breast
cancer cell proliferation and invasion, and decrease the gene expression in
breast cancer cells, thus lowering tumor aggressiveness and significantly
reducing its size (McAllister, et al., 2007). CBD acid (CBDA) has
shown the capability of down-regulating invasive human brain cancer cells and
therefore preventing their growth (Takeda, et al., 2014) (McAllister, et al.,
2011).
심혈관 질환 Cardiovascular Disease
CBD는 심혈관질환의 치료에 집합적으로 치료효과를 제공하는 심근기능장애, 심장섬유증, 산화- 질산 스트레스, 염증, 세포사멸 및 상호 연관된 신호전달 경로를 감소시킵니다(Rajesh, et al., 2010).
또한, 심장발작 직후에 CBD를 투여하면 경색 크기 및 심근염증을 감소시켜 심근 허혈에 대한 치료제로서의 가능성을 보여 주었습니다(Durst, et al., 2007).
CBD reduces myocardial dysfunction,
cardiac fibrosis, oxidative-nitrative stress, inflammation, cell death, and
interrelated signaling pathways, which collectively offers therapeutic benefits
in the treatment of cardiovascular diseases (Rajesh, et al., 2010). In
addition, administering CBD shortly
after a heart attack has been shown to reduce infarct size and myocardial
inflammation, thus showing potential as a treatment for myocardial ischemia
(Durst, et al., 2007).
경변증 (간질환) Cirrhosis (Liver Disease)
연구에 따르면 CBD는 증식하고 과도한 콜라겐을 생성하여 간에서 흉터가 축적되는 간 성상 세포(HSC)의 사멸을 돕는 방법으로 간경변 진행에 도움을 줍니다(Lim, Devi & Rozenfeld, 2011).
CBD는 또한 간기능 부전을 겪는 쥐에서 간기능을 회복시키는 것으로 밝혀졌습니다 (Abraham, et al., 2011).
또한 CBD는 주요 염증 경로와 산화/질화 조직 손상의 힘을 줄임으로써 간경화에서 조직 손상의 중추적 메커니즘인 허혈 재관류를 예방합니다 (Mukhopadhyay, Rajesh & Pacher,
2011).
Studies suggest that CBD helps
combat cirrhosis progression by assisting in the death of hepatic stellate
cells (HSCs), which proliferate and produce excess collagen, causing the
accumulation of scarring on the liver (Lim, Devi & Rozenfeld, 2011). CBD has also been shown to restore
liver function in mice experiencing liver failure (Abraham, et al., 2011). In
addition, CBD provide protection
against ischemia reperfusion, the pivotal mechanism of tissue damage in
cirrhosis, by reducing the force of key inflammatory pathways and
oxidative/nitrative tissue injury (Mukhopadhyay, Rajesh & Pacher, 2011).
크론병(과민성대장증후군) Crohn’s Disease (Irritable Bowel Syndrome)
CBD는 소화기 궤양의 항염증제를 지원합니다(Esposito, et al., 2013) (De
Filippis, et al., 2011).
CBD는 질병으로 인한 친-염증반응을 조절할 수 있습니다 (De Filippis, et al., 2011).
CBD supports anti-inflammation of
the digestive track (Esposito, et al., 2013) (De Filippis, et al., 2011). CBD is able to control the
pro-inflammatory response caused by the disease (De Filippis, et al., 2011).
우울증 Depression
CBD는 동물모델에서 항-우울 효과와 항-불안 효과를 입증했습니다(de Mello Schier, et al., 2014)
(Zanelati, et al., 2010).
CBD has demonstrated both antidepressant
and anti-anxiety effects in animal models (de Mello Schier, et al., 2014)
(Zanelati, et al., 2010).
당뇨병 Diabetes
CBD는 혈류에서의 전-염증성 사이토카인과 비만(non-obese) 쥐에서의 당뇨병 발병률을 현저하게 감소시키는 것으로 나타났습니다(Weiss, et al., 2006).
또한 질병의 증상을 줄이는데 효과적임이 밝혀졌습니다(Weiss, et al.,
2008).
연구에 따르면 CBD치료가 당뇨병성 망막증에서 상당한 보호를 제공한다는 사실도 발견되었습니다 (El-Remessy,
et al., 2006).
CBD has shown to significantly
reduce pro-inflammatory cytokines in the bloodstream and the incidence of
diabetes in non-obese mice (Weiss, et al., 2006). It’s also been shown to be
effective at curtailing the manifestations of the disease (Weiss, et al.,
2008). Research has also found that CBD
treatments provide significant protection from diabetic retinopathy
(El-Remessy, et al., 2006).
간질 및 발작 장애 Epilepsy and Seizure Disorders
CBD는 발작을 줄이거나 없애는 능력을 보여 주었습니다(Blair, Deshpande & DeLorenzo,
2015) (Rosenberg, Tsien, Whalley & Devinsky, 2015) (Szaflarski & Bebin,
2014) (Devinsky, et al., 2014).
또한 칸나비스가 드라베트 증후군, 두세 증후군, 레녹스-가스토 증후군과 같은 심각한 소아 간질장애의 치료에 효과적이라는 연구 결과가 있습니다(Porter &
Jacobson, 2013).
CBD는 간질 어린이에서 수면(53%), 기민성(71%) 및 기분(63%)을 향상시키는 것으로 나타났습니다(Hussain, et al.,
2015).
CBD has demonstrated the ability to
reduce or even eliminate seizures (Blair, Deshpande & DeLorenzo, 2015)
(Rosenberg, Tsien, Whalley & Devinsky, 2015) (Szaflarski & Bebin, 2014)
(Devinsky, et al., 2014). Research also finds that cannabis is effective in the
treatment of severe pediatric epilepsy disorders like Dravet syndrome, Doose
syndrome and Lennox-Gastaut syndrome (Porter & Jacobson, 2013). CBD has also been shown to improve
sleep (53%), alertness (71%), and mood (63%) in epileptic children (Hussain, et
al., 2015).
백혈병 Leukemia
CBD는 백혈병 환자가 줄기세포 또는 골수이식 받은 후 발생할 수 있는 합병증 예방에 도움이 됩니다(Yeshurun, et al., 2015).
또한 암환자가 전통적 암 치료와 관련된 메스꺼움, 구토 및 통증을 관리하고 식욕을 자극하도록 도와주는 것으로 밝혀졌습니다(Guzman, 2003).
CBD helps prevent complications that
can occur after a leukemia patient receives a stem cell or bone marrow
transplant (Yeshurun, et al., 2015). In addition, it has been found to help
cancer patients manage the nausea, vomiting and pain associated with
traditional cancer treatments and to stimulate appetite (Guzman, 2003).
편두통 Migraines
CBD는 두통과 편두통을 포함한 다양한 상태와 관련된 통증을 감소시키는 데 효과적입니다 (Baron, 2015).
CBD is effective at reducing pain
associated with a wide variety of conditions, including headache and migraines
(Baron, 2015).
다발성 경화증 Multiple Sclerosis
CBD는 다발성경화증과 관련된 염증과 싸우므로 신경보호를 제공하고 질병 진행을 제한합니다 (Kozela, et al,
2011) (Mecha, et al., 2013).
CBD는 다발성경화증으로 인한 경련을 효과적으로 감소시킵니다(Collin, et al., 2010).
또한, 다발성경화증과 관련된 신경병성 통증을 감소시킬 수 있는 능력을 보여 주었습니다 (Barnes, 2006).
CBD combats the inflammation
associated with multiple sclerosis, therefore providing neuroprotection and
limiting the disease’s progression (Kozela, et al, 2011) (Mecha, et al., 2013).
CBD effectively reduces the
spasticity caused by multiple sclerosis (Collin, et al., 2010). In addition, it
has demonstrated the ability to reduce the neuropathic pain associated with
multiple sclerosis (Barnes, 2006).
구역질 Nausea
연구에 따르면 칸나비스에 들어있는 CBD를 포함한 칸나비노이드는 메스꺼움 증상을 조절하기 어렵고 화학요법 환자에서 예상되는 구역을 예방하는 데 효과적입니다(Parker, Rock
& Limbeer, 2011).
Studies have found that cannabinoids, including CBD contained in cannabis, are effective at treating the more
difficult to control symptoms of nausea, as well as preventing anticipatory
nausea in chemotherapy patients (Parker, Rock & Limbeer, 2011).
비만 Obesity
CBD는 체중 증가를 현저하게 감소시키고 지질 수준을 감소시키는 것으로 나타났습니다
(Ignatowska-Jankowska, Jankowski & Swiergiel, 2011) (Silvestri, et al.,
2015).
CBD has been shown to cause a
significant decrease in body weight gain and reduce lipid levels
(Ignatowska-Jankowska, Jankowski & Swiergiel, 2011) (Silvestri, et al.,
2015).
통증 Pain
CBD는 경련, 두통, 편두통 및 기타 급성 통증 및 만성통증 질환(Jensen, Chen, Furnish & Wallace, 2015)
(Baron, 2015)와 같은 다양한 조건과 관련된 통증 수준을 낮추는데 효과적입니다.
CBD has been shown effective at
lowering pain levels associated with a wide variety of conditions, including
spasticity, headache, migraines, and other acute pain and chronic pain
conditions (Jensen, Chen, Furnish & Wallace, 2015) (Baron, 2015).
파킨슨 병 Parkinson’s Disease
CBD는 신경보호 성질이 있으며 신경세포 미토콘드리아의 건강을 돕고, 따라서 신경퇴화를 예방하는데 도움을 준다(Silva, et al., 2014)(Zuardi,
2008)(Fernandez-Ruiz, et al., 2013).
CBD 치료를 받는 파킨슨병 환자의 삶의 질이 크게 향상되었습니다(Chagas, et al., 2014).
CBD는 정신병을 앓는 파킨슨병 환자에게 도움이 될 수 있습니다(Zuardi, et al.,
2009).
CBD has neuroprotective properties
and supports the health of neural cells mitochondria, thus helping to prevent
neurodegeneration (da Silva, et al., 2014) (Zuardi, 2008). (Fernandez-Ruiz, et
al., 2013). Significant improvements in well being and quality of life scores
were found in Parkinson’s disease patients undergoing CBD treatment (Chagas, et al., 2014). CBD may help with those Parkinson’s’ disease patients experiencing
psychosis (Zuardi, et al., 2009).
외상 후 스트레스 장애 (PTSD) Post-Traumatic Stress Disorder (PTSD)
CBD와 endocannabinoid 계통의 칸나비노이드 수용체(CB1과 CB2)의 상호작용은 즐거움을 증가시키고 기억 과정의 교대를 시작하는 신경전달 물질의 방출을 조절합니다(Betthauser,
Piilz, Vollmer, 2015).
CBD는 또한 외상 사건의 연속적 검색을 막을 수 있기 때문에 확장을 강화하고 관련 불안을 줄일 수 있습니다(Akirav, 2013)
(Trezza & Campolongo, 2013) (Passie, et al., 2012).
CBD’s interaction with the
cannabinoid receptors (CB1 and CB2) of the endocannabinoid system modulates the
release of neurotransmitter that increases a sense of pleasure and initiates
alternation of memory processes (Betthauser, Piilz, Vollmer, 2015). CBD can also block the continuous
retrieval of the traumatic event, thus enhancing its extension and reducing its
associated anxiety (Akirav, 2013) (Trezza & Campolongo, 2013) (Passie, et
al., 2012).
정신분열병 Schizophrenia
CBD는 항-불안증 및 항-향정신성 약물을 함유하고 있습니다.
임상 시험에서 CBD로 치료받은 정신분열증 환자는 CBD가 정신분열병에 대한 안전하고 내약성이 뛰어난 대체 치료제임을 보여 주었습니다(Zuardi, et al.,
2006) (Leweke, et al., 2012).
CBD has anxiolytic and antipsychotic
properties. Schizophrenia patients treated with CBD in trials have shown that CBD
is a safe and well-tolerated alternative treatment for schizophrenia (Zuardi,
et al., 2006) (Leweke, et al., 2012).
겸상적혈구빈혈 Sickle Cell Anemia
칸나비노이드는 겸상적혈구질환과 관련된 심한 통증을 줄여주는 것으로 나타났습니다 (Kohli,
et al., 2010) (Howard, et al., 2005).
Cannabinoids have shown to be effective at helping curtail the severe pain
associated with sickle cell disease (Kohli, et al., 2010) (Howard, et al.,
2005).
척수 질환 Spinal Cord Disease
CBD는 척수질환 및 손상 환자에서 방광조절, 근육경련 및 경련을 개선합니다(Wade, et al,
2003).
CBD improves bladder control, muscle
spasms and spasticity in patients with spinal cord diseases and damage (Wade,
et al, 2003).
척수 부상 Spinal Cord Injuries
척수 손상 직후에 관리하면 CBD는 신경보호 반응을 자극하여 손상을 제한합니다(Arevalo-Martin,
et al., 2012).
CBD는 척수손상 후 운동 점수를 향상시키는 것으로 나타났습니다 (Kwiatkoski, et al, 2012).
When administered shortly after a spinal cord injury, CBD stimulates a neuroprotective response to limit damage
(Arevalo-Martin, et al., 2012). CBD
has shown to improve motor scores following a spinal cord injury (Kwiatkoski,
et al, 2012).
뇌졸증 Stroke
뇌졸중 직후 CBD를 투여하면 신경세포와 성상 세포가 손상되지 않도록 보호하여, 기능적, 조직학적, 생화학적 및 신경행동 회복이 향상됩니다(Lafuente, et al., 2011).
Administering CBD shortly after a
stroke protects neurons and astrocytes from damage, and therefore leads to
improved functional, histological, biochemical, and neurobehavior recovery
(Lafuente, et al., 2011).
외상성 뇌 손상 Traumatic Brain Injury
CBD는 신경보호 효능을 제공하고 외상성 뇌손상 후 뇌손상을 제한하는 것으로 나타났습니다 (Castillo, et al., 2010) (Mechoulam
& Shohami, 2007) (Pazos, et al., 2013).
CBD has shown to provide a
neuroprotective effect and limit brain damage following a traumatic brain
injury (Castillo, et al., 2010) (Mechoulam & Shohami, 2007) (Pazos, et al.,
2013).
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